Self-limiting Action of Nicotine on Brain Reward
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چکیده
Previous work has shown that nicotine facilitates brain stimulation reward (BSR) but that the maximum effect obtainable with nicotine is similar to that seen with compounds having a low addiction liability (e.g., caffeine, diphenhydramine, pseudoephedrine). Two studies further explored nicotine’s effects on BSR using a threshold-tracking procedure. Male, Long-Evans rats were implanted with stimulating electrodes at the lateral hypothalamic level of the medial forebrain bundle. Nicotine bitartrate (doses expressed as the freebase weight) was injected subcutaneously, and its effects on BSR were measured 15-30 min post injection.
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تاریخ انتشار 1997